144 0001752631 XXXXXXXX LIVE 0001484565 SOLENO THERAPEUTICS INC 001-36593 100 MARINE PARKWAY, SUITE 400 REDWOOD CITY CA 94065 650-213-8444 Meredith Manning Officer Common Stock ETrade Financial Corporation

P.O. Box 484 Jersey City NJ 07303

48000 2402400.00 45857291 03/27/2025 NASDAQ Common Stock 03/26/2025 Vesting of Restricted Stock Units - See Remarks Issuer N 11000 03/26/2025 Equity Compensation Common Stock 03/27/2025 Stock option exercises Issuer N 37000 03/27/2025 Cash Y Approximately 11,000 shares to be sold to cover tax withholding obligations in connection with the vesting of restricted stock units. 03/27/2025 /s/ Meredith Manning