X0306 4 2023-01-17 0 0001576885 Acumen Pharmaceuticals, Inc. ABOS 0001752461 Meisner Derek M C/O ACUMEN PHARMACEUTICALS, INC. 427 PARK STREET CHARLOTTESVILLE VA 22902 0 1 0 0 Chief Legal Office & Corp Sec Common Stock 2023-01-17 4 A 0 26800 0.00 A 26800 D Employee Stock Option (right to buy) 6.11 2023-01-17 4 A 0 120800 0.00 A 2033-01-16 Common Stock 120800 120800 D Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date. The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date. /s/ Katherine Denby, Attorney-in-Fact 2023-01-18