X0306 4 2022-06-06 0 0001396814 Pacira BioSciences, Inc. PCRX 0001752004 McLoughlin Dennis C/O PACIRA BIOSCIENCES, INC. 5401 WEST KENNEDY BOULEVARD, SUITE 890 TAMPA FL 33609 0 1 0 0 Chief Customer Officer Common Stock 2022-06-06 4 S 0 2140 61.374 D 31820 D Common Stock 2022-06-08 4 A 0 7950 0.00 A 39770 D Stock Option (Right to Buy) 59.39 2022-06-08 4 A 0 19900 0.00 A 2032-06-08 Common Stock 19900 19900 D Represents shares sold by the reporting person to cover tax obligations upon the vesting of restricted stock units. Includes 258 and 161 shares of common stock acquired under the issuer's employee stock purchase plan in June 2021 and December 2021, respectively. Represents restricted stock units that vest in four equal annual installments beginning on June 3, 2023, provided that the reporting person remains in continuous service with the issuer as of each vesting date. Each restricted stock unit represents the contingent right to receive one share of the issuer's common stock. The stock option vests and becomes exercisable as to 25% of the option shares on the first anniversary of the grant date, and vests as to the remaining shares in successive equal quarterly installments over the subsequent three years, provided that the reporting person remains in continuous service with the issuer as of each vesting date. /s/ Kristen Williams, Attorney-in-Fact 2022-06-08