X0306 4 2022-03-10 0001101239 EQUINIX INC EQIX 0001751921 Miller Simon C/O EQUINIX, INC. ONE LAGOON DRIVE REDWOOD CITY CA 94065 1 Chief Accounting Officer Common Stock 2022-03-10 4 M 0 318 0 A 3963 D Common Stock 2022-03-11 4 S 0 1 695.97 D 3962 D Common Stock 2022-03-11 4 S 0 39 697.7307 D 3923 D Common Stock 2022-03-11 4 S 0 14 698.8724 D 3909 D Common Stock 2022-03-11 4 S 0 72 699.7962 D 3837 D Common Stock 2022-03-11 4 S 0 25 700.8447 D 3812 D Common Stock 2022-03-11 4 S 0 40 701.9164 D 3772 D Common Stock 2022-03-11 4 S 0 26 702.9543 D 3746 D Common Stock 2022-03-11 4 S 0 11 704.1921 D 3735 D Common Stock 2022-03-11 4 S 0 30 705.3342 D 3705 D Common Stock 2022-03-11 4 S 0 25 706.2074 D 3680 D Common Stock 2022-03-11 4 S 0 6 707.0733 D 3674 D Common Stock 2022-03-11 4 S 0 6 708.48 D 3668 D Common Stock 2022-03-11 4 S 0 2 709.295 D 3666 D Common Stock 2022-03-11 4 S 0 21 710.82 D 3645 D Restricted Stock 0 2022-03-10 4 A 0 318 0 A Common Stock 318 318 D Restricted Stock 0 2022-03-10 4 M 0 318 0 D Common Stock 318 0 D Shares sold pursuant to a 10b5-1 Trading Plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $697.19 to $698.15, inclusive. The reporting person undertakes to provide to Equinix, Inc, any security holder of Equinix Inc, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes 2 through 11 to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $698.29 to $699.29 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $699.325 to $700.32 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $700.34 to $701.28 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $701.44 to $702.42 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $702.53 to $703.42 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $703.71 to $704.635 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $704.83 to $705.80 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $705.865 to $706.76 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $706.99 to $707.23 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $708.36 to $708.72 inclusive. Under the 2020 Annual Incentive Plan, subject to meeting performance criteria, the reporting person was eligible to receive a bonus to be paid in the form of fully-vested restricted stock units. The Compensation Committee has determined that the performance criteria were attained, and therefore 100% of the award was granted on March 10, 2022 as reported in this Form 4. Restricted stock unit award expires upon reporting person's termination of service. /s/ Samantha Lagocki, POA 2022-03-14