X0306 4 2020-12-27 0 0000805928 Axogen, Inc. AXGN 0001751541 Scopelianos Angelo 13631 PROGRESS BOULEVARD SUITE 400 ALACHUA FL 32615 0 1 0 0 VP Research & Development Common Stock 2020-12-27 4 A 0 2300 A 6096 D Common Stock 2020-12-29 4 S 0 567 17.81 D 5529 D This reflects the number of restricted stock units that became vested as of December 27, 2020. Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units granted on December 27, 2018. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the reporting person. Includes 1547 shares acquired under the Axogen, Inc. employee stock purchase plan on June 30, 2020. /s/ Angelo Scopelianos 2020-12-30