<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-03-08</periodOfReport>

    <issuer>
        <issuerCik>0000068505</issuerCik>
        <issuerName>Motorola Solutions, Inc.</issuerName>
        <issuerTradingSymbol>MSI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001751240</rptOwnerCik>
            <rptOwnerName>PEKOFSKE DANIEL G</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>MOTOROLA SOLUTIONS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>500 WEST MONROE ST.</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60661</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>CVP and CAO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Motorola Solutions, Inc. - Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-03-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>F</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>185</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>214.13</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3038.1568</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Includes shares acquired through the reinvestment of dividends.</footnote>
    </footnotes>

    <remarks>Exhibit 24 - Power of Attorney - CE</remarks>

    <ownerSignature>
        <signatureName>Lauren E. Henderson, on behalf of Daniel G. Pekofske, Corporate Vice President and Chief Accounting Officer (Power of Attorney Attached)</signatureName>
        <signatureDate>2022-03-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
