Commitments and Contingencies - Additional Information (Details) $ in Thousands				1 Months Ended	12 Months Ended
	Nov. 29, 2024 USD ($)	Jun. 28, 2024 USD ($)	Sep. 05, 2023 USD ($)	Jun. 30, 2022 USD ($)	Dec. 31, 2024 USD ($) Item	Dec. 31, 2023 USD ($)
Loss Contingencies [Line Items]
Reimbursable research and development costs from a collaboration partner					$ 0	$ 1,491
Research and development					124,517	86,140
Senior Secured Loan Facility
Loss Contingencies [Line Items]
Term of loan agreement			4 years
Aggregate principal amount			$ 50,000
Amount available for draw down, Private placement.			25,000
Amount available for draw down, Lenders discretion			$ 25,000		$ 25,000
Maturity date			Aug. 01, 2027
Interest rate			8.00%
Incremental interest rate at the event of default			3.00%
Unused commitment fee percentage			1.50%
Amendment of Original Loan Agreement
Loss Contingencies [Line Items]
Aggregate principal amount		$ 100,000
Amount currently available for draw down		25,000
Amount available for draw down upon achieving certain milestones related to execution of first line pivotal phase 3		25,000
Amount available for draw down, Lenders discretion		$ 50,000
Maturity date		Jul. 01, 2028
Novartis Pharma Agreement
Loss Contingencies [Line Items]
Exclusive negotiation period after receipt of written notice	30 days
Exclusive negotiation period maximum	120 days
Proposed sale negotiation period	45 days
Aggregate amount of units actually supplied	$ 275,000
Novartis Pharma Agreement | Bio Medical Research Inc
Loss Contingencies [Line Items]
Number of patients | Item					60
Costs reimbursable from Novartis					$ 0	2,000
Reimbursable research and development costs from a collaboration partner						$ 1,500
Aurigene Agreement
Loss Contingencies [Line Items]
Milestone payments to be paid to collaborative partner				$ 60,000
Upfront payment, research and development.				8,000
Research and development					0
Aurigene Agreement | Clinical Cevelopment and Regulatory Milestones
Loss Contingencies [Line Items]
Research and development					$ 5,000
Aurigene Agreement | Commercial Milestone
Loss Contingencies [Line Items]
Milestone payments to be paid to collaborative partner				$ 370,000