Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Operating Loss Carryforwards [Line Items]
Accrued interest or penalties related to uncertain tax positions	$ 0	$ 0
Earliest Tax Year
Operating Loss Carryforwards [Line Items]
Income tax year open to examination	2018
Latest Tax Year
Operating Loss Carryforwards [Line Items]
Income tax year open to examination	2022
United Kingdom
Operating Loss Carryforwards [Line Items]
Corporation tax rate percentage		25.00%
Increase in net deferred tax assets		$ 38,800,000
Increase in valuation allowance		38,800,000
Operating loss carryforwards	$ 633,400,000	506,200,000
US | Federal | Orphan Drug
Operating Loss Carryforwards [Line Items]
Tax credits carryforward, amount	700,000	600,000
US | State | Research and Development
Operating Loss Carryforwards [Line Items]
Tax credits carryforward, amount	$ 2,200,000	$ 2,400,000
Tax credit carryforward expiration year	2042