Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Cash flows from operating activities
Net loss attributable to ordinary shareholders	$ (150,660)	$ (144,584)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	2,741	2,327
Share-based compensation	16,010	22,536
Non-cash interest expense	372	392
Amortization of provision on loss contract	(274)	(1,037)
Deferred income taxes	(3,283)	1,131
Amortization of premium (discount) on marketable securities	(305)	1,514
Unrealized foreign currency and other non-cash adjustments	23,208	9,687
Changes in operating assets and liabilities:
Accounts receivable	(7,420)	(624)
Research and development tax credit receivable	22,568	(13,920)
Prepaid expenses, other current assets, and other assets	5,053	(5,209)
Operating leases, right-of-use-assets	5,431	5,938
Accounts payable, accrued expenses, and other current liabilities	13,642	(9,452)
Deferred revenue	(272)	13,122
Other long-term liabilities	2,154	34
Operating lease liabilities	(4,952)	(6,952)
Net cash used in operating activities	(75,987)	(125,097)
Cash flows from investing activities
Proceeds from sales and maturities of marketable securities	201,389	234,732
Purchases of marketable securities	(112,281)	(263,878)
Receipt of funds from construction deposit	7,966	216
Payments on intangible assets		(887)
Purchases of property and equipment	(6,514)	(2,348)
Net cash provided by (used in) investing activities	90,560	(32,165)
Cash flows from financing activities
Proceeds from modification of credit facility, net of debt issuance costs paid		7,375
Proceeds from employee equity plans	212	3,303
Payment of taxes on restricted stock vesting	(19)	(392)
Proceeds from issuance of shares as part of collaboration agreement		4,135
Proceeds from the issuance of ordinary shares in private placement		150,000
Payment of placement agent fees and offering costs	(100)	(6,355)
Repayment of notes payable	(786)
Net cash (used in) provided by financing activities	(693)	158,066
Effect of exchange rate changes on cash	(1,419)	(27)
Net increase in cash, cash equivalents and restricted cash	12,461	777
Cash, cash equivalents, and restricted cash —beginning of year	60,178	59,401
Cash, cash equivalents, and restricted cash —end of year	72,639	60,178
Supplemental disclosure of non-cash investing and financing activities
Intangible assets and property and equipment in accounts payable and accrued expenses	60	2,589
Supplemental disclosure of cash flow information
Lease assets obtained in exchange for new operating lease liabilities	4,912	552
Changes to operating lease right-of-use assets and liabilities from amendments	530
Cash paid for interest	2,648	2,103
Cash paid for taxes	$ 157	$ 1,651