Leases - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended						12 Months Ended
	Mar. 31, 2022	Jul. 31, 2021	Jul. 31, 2019	Dec. 31, 2018	Mar. 31, 2018	Jan. 31, 2018	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Operating Leases [Line Items]
Operating leases expiration term							Jul. 02, 2025
Sublease income							$ 2,820	$ 2,746
Operating lease right-of-use-assets							22,774	24,316
Operating lease liabilities							25,670
Outstanding letter of credit associated with a lease							3,000	3,000
Operating lease, liability, noncurrent							19,246	19,278
Operating lease, right-of-use asset obtained in exchange for lease liabilities							6,100	600
Rental Lab Space [Member]
Operating Leases [Line Items]
Annual rental payment							200	200
Ten Years Lease Term Expires In February 2032 [Member] | Office Space London United Kingdom Lease Agreement [Member]
Operating Leases [Line Items]
Operating leases expiration term	Feb. 28, 2032
Lessee, operating Lease, existence of option to extend [true false]	false
Five Years Lease Term Terminates In January 2023 [Member] | Office Space London United Kingdom Lease Agreement [Member]
Operating Leases [Line Items]
Operating leases expiration term				Jan. 31, 2023		Jan. 31, 2023
Annual rental payment							1,700	1,800
Lessee, operating Lease, existence of option to extend [true false]				false		false
Lease Term Terminates in September 2022 [Member] | Office Space Boston Lease Agreement [Member]
Operating Leases [Line Items]
Operating leases expiration term					Sep. 30, 2022
Annual rental payment							300	400
Sublease income							200	100
Lease Term Terminates in September 2026 [Member] | Office Space Boston Lease Agreement [Member]
Operating Leases [Line Items]
Operating leases expiration term			Sep. 30, 2026
Annual rental payment							1,200	1,100
Operating leases Commenced term			Jan. 31, 2020
Lessee, operating Lease, existence of option to extend [true false]		false
Boston and London Office Space Lease Agreements [Member]
Operating Leases [Line Items]
Operating lease right-of-use-assets							8,100	4,100
Operating lease liabilities							8,700	4,300
Fremont Lease Agreement [Member]
Operating Leases [Line Items]
Operating leases expiration term				May 31, 2030
Annual rental payment							3,200	3,100
Operating lease duration for free rent				8 months
Operating lease right-of-use-assets							8,800
Reduction of standby letter of credit amount percentage				25.00%
Outstanding letter of credit associated with a lease				$ 3,000
Operating lease, liability, noncurrent							12,000
Fremont Lease Agreement [Member] | Maximum [Member]
Operating Leases [Line Items]
Tenant improvements allowance							5,300
Fremont Sublease Agreement
Operating Leases [Line Items]
Operating lease duration for free rent									12 months
Fremont Sublease Agreement | Other Long-Term Liabilities [Member]
Operating Leases [Line Items]
Security deposit									$ 2,600
Fremont Sublease Agreement | Maximum [Member]
Operating Leases [Line Items]
Tenant improvements allowance									$ 5,300
G S K Agreement
Operating Leases [Line Items]
Annual rental payment							2,500	3,100
Operating lease right-of-use-assets							5,800	10,700
Operating lease, liability, noncurrent							$ 5,300	$ 9,300
Operating lease term							5 years
Lessee, operating lease, option to extend							The agreement may be extended for an additional two years by mutual agreement of the Company and AGC
Lessee, operating Lease, existence of option to extend [true false]							true
Operating lease extended term							2 years