Restructuring Charges - Additional Information (Details) - USD ($)	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021
Restructuring Cost And Reserve [Line Items]
Research and development	$ 93,847,000	$ 86,977,000
Selling, general and administrative	49,125,000	54,905,000
Restructuring costs	2,481,000	$ 0
Neurometabolic Diseases and Early Research Programs
Restructuring Cost And Reserve [Line Items]
Research and development	1,400,000
Selling, general and administrative	300,000
Neurometabolic Diseases and Early Research Programs \| Employee-Related Termination Costs
Restructuring Cost And Reserve [Line Items]
One-time charge	$ 1,700,000

The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
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Amount of expenses associated with exit or disposal activities pursuant to an authorized plan. Excludes expenses related to a discontinued operation or an asset retirement obligation.

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Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc.

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