Nature of the Business and Liquidity - Additional Information (Details)				12 Months Ended
	Mar. 10, 2023 USD ($) shares	Mar. 06, 2023 £ / shares shares	Feb. 09, 2021 USD ($) shares	Dec. 31, 2022 USD ($) VotingRight	Dec. 31, 2021 USD ($)	Mar. 10, 2023 £ / shares shares	Mar. 10, 2023 $ / shares shares	Dec. 31, 2022 £ / shares	Dec. 31, 2022 USD ($)	Dec. 31, 2021 £ / shares	Feb. 09, 2021 £ / shares	Feb. 09, 2021 $ / shares
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Ordinary shares voting rights description				As of December 31, 2022, each holder of ordinary shares and ADSs is entitled to one vote per ordinary share
Number of ordinary voting rights | VotingRight				1
Ordinary shares dividends declared				$ 0	$ 0
Nominal value of shares issued and sold | £ / shares								£ 0.10		£ 0.10
Placement agent fees				$ 100,000	$ 6,355,000
Cash, cash equivalents and marketable securities									$ 143,800,000
Subsequent Event
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of ordinary shares issued and sold | shares	56,666,900
Nominal value of shares issued and sold | £ / shares						£ 0.10
Warrants to purchase ordinary shares | shares						62,333,590	62,333,590
Warrants to purchase price per share | $ / shares							$ 6.00
2023 Private Placement | Subsequent Event
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Gross proceeds of offering	$ 34,000,000.0
Securities Purchase Agreement | Private Placement
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of ordinary shares issued and sold | shares			20,900,321
Nominal value of shares issued and sold | £ / shares											£ 0.10
Purchase price per share | $ / shares												$ 6.22
Closing price of share date			Feb. 04, 2021
Securities Purchase Agreement | Private Placement | Non-voting Ordinary Shares
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of ordinary shares issued and sold | shares			3,215,434
Nominal value of shares issued and sold | £ / shares											£ 0.10
Securities Purchase Agreement | 2021 Private Placement
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Placement agent fees			$ 6,000,000.0
Other issuance costs			400,000
Net proceeds from private placement			$ 143,600,000
Securities Purchase Agreement | 2023 Private Placement | Subsequent Event
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of ordinary shares issued and sold | shares		99,166,900
Nominal value of shares issued and sold | £ / shares		£ 0.10
Warrants to purchase ordinary shares | shares		109,083,590
Securities Purchase Agreement | 2023 Private Placement | Non-voting Ordinary Shares | Subsequent Event
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Nominal value of shares issued and sold | £ / shares		£ 0.10