Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Total revenues	$ 22,655	$ 1,675
Costs and operating expenses
Cost of product revenue	6,771	226
Research and development	93,847	86,977
Selling general and administrative	49,125	54,905
Total costs and operating expenses	149,743	142,108
Loss from operations	(127,088)	(140,433)
Other (expense) income:
Interest income	1,543	412
Interest expense	(3,079)	(2,497)
Other (expense) income, net	(24,410)	(1,238)
Total other (expense) income, net	(25,946)	(3,323)
Net loss before income tax	(153,034)	(143,756)
Income tax (expense) benefit	2,374	(828)
Net loss attributable to ordinary shareholders	$ (150,660)	$ (144,584)
Net loss per share attributable to ordinary shareholders, basic	$ (1.18)	$ (1.17)
Net loss per share attributable to ordinary shareholders, diluted	$ (1.18)	$ (1.17)
Weighted average number of ordinary shares outstanding, basic	127,975,062	123,963,762
Weighted average number of ordinary shares outstanding, diluted	127,975,062	123,963,762
Other comprehensive income (loss)
Foreign currency translation	$ 22,838	$ 3,124
Unrealized loss on marketable debt securities	(66)	(251)
Total other comprehensive income (loss)	22,772	2,873
Total comprehensive loss	(127,888)	(141,711)
Product Revenue, Net [Member]
Total revenues	20,610	700
Collaboration Revenue [Member]
Total revenues	$ 2,045	$ 975