The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Restructuring Charges - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Restructuring Cost And Reserve [Line Items]
Research and development	$ 21,965	$ 21,750	$ 50,199	$ 42,785
Selling, general and administrative	$ 13,730	$ 14,263	27,029	$ 28,314
Neurometabolic Diseases and Early Research Programs
Restructuring Cost And Reserve [Line Items]
Research and development			1,600
Selling, general and administrative			400
Employee-Related Termination Costs \| Neurometabolic Diseases and Early Research Programs
Restructuring Cost And Reserve [Line Items]
One-time charge			$ 1,900