Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss attributable to ordinary shareholders	$ (95,212)	$ (71,791)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,366	1,003
Share-based compensation	8,616	11,809
Non-cash interest expense	186	200
Amortization of provision on loss contract	(276)	(814)
Amortization of premium on marketable securities	189	761
Unrealized foreign currency and other non-cash adjustments	25,092	7,657
Changes in operating assets and liabilities:
Accounts receivable	(2,997)	893
Research and development tax credit receivable	13,289	(7,800)
Prepaid expenses, other current assets and other assets	769	(543)
Operating leases, right-of-use assets	2,777	2,518
Accounts payable, accrued expenses and other current liabilities	4,251	(14,341)
Deferred revenue	(138)
Operating lease liabilities	(3,887)	(4,846)
Net cash used in operating activities	(45,975)	(75,294)
Cash flows from investing activities:
Proceeds from sales and maturities of marketable securities	97,214	133,511
Purchases of marketable securities	(50,891)	(166,966)
Purchases of property and equipment	(1,572)	(935)
Receipt of funds from construction deposit		199
Net cash provided by (used in) investing activities	44,751	(34,191)
Cash flows from financing activities:
Proceeds from employee equity plans, net of taxes withheld	137	2,836
Proceeds from the issuance of ordinary shares in private placement		150,000
Payment of placement agent fees and offering costs		(6,355)
Proceeds from modification of credit facility, net of debt issuance costs paid		7,375
Net cash provided by financing activities	137	153,856
Effect of exchange rate changes on cash, cash equivalents, and restricted cash	(1,355)	423
Net increase (decrease) in cash, cash equivalents and restricted cash	(2,442)	44,794
Cash, cash equivalents, and restricted cash, beginning of period	60,178	59,401
Cash, cash equivalents, and restricted cash, end of period	57,736	104,195
Supplemental disclosure of non-cash activities
Property and equipment and intangible assets included in accounts payable and accrued expenses	1,046	2,860
Supplemental disclosure of cash flow information:
Lease assets obtained in exchange for new operating lease liabilities, net	4,912	386
Non-cash adjustments to operating lease right-of-use assets and liabilities	530
Cash paid for interest	$ 1,153	$ 931