Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Total revenue	$ 4,368		$ 9,892
Costs and operating expenses:
Cost of product revenue	1,122		2,693
Research and development	21,965	$ 21,750	50,199	$ 42,785
Selling, general and administrative	13,730	14,263	27,029	28,314
Total costs and operating expenses	36,817	36,013	79,921	71,099
Loss from operations	(32,449)	(36,013)	(70,029)	(71,099)
Other income (expense):
Interest income	213	113	282	284
Interest expense	(672)	(593)	(1,347)	(1,131)
Other income (expense), net	(18,227)	634	(24,279)	1,992
Total other income (expense), net	(18,686)	154	(25,344)	1,145
Loss before income taxes	(51,135)	(35,859)	(95,373)	(69,954)
Income tax (expense) benefit	219	(750)	161	(1,837)
Net loss attributable to ordinary shareholders	$ (50,916)	$ (36,609)	$ (95,212)	$ (71,791)
Net loss per share attributable to ordinary shareholders, basic	$ (0.40)	$ (0.29)	$ (0.75)	$ (0.60)
Net loss per share attributable to ordinary shareholders, diluted	$ (0.40)	$ (0.29)	$ (0.75)	$ (0.60)
Weighted average ordinary shares outstanding, basic	127,854,596	125,952,834	127,775,132	120,421,781
Weighted average ordinary shares outstanding, diluted	127,854,596	125,952,834	127,775,132	120,421,781
Other comprehensive income (loss):
Foreign currency translation	$ 17,450	$ (374)	$ 23,045	$ (438)
Unrealized loss on marketable securities	(1)	(8)	(261)	(121)
Total other comprehensive income (loss):	17,449	(382)	22,784	(559)
Total comprehensive loss	(33,467)	$ (36,991)	(72,428)	$ (72,350)
Product Revenue, Net [Member]
Total revenue	3,781		8,840
Collaboration Revenue [Member]
Total revenue	$ 587		$ 1,052