Basis of Presentation and Summary of Significant Accounting Policies - Summary of Amounts recognized to Offset Research and Development Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Summary Of Significant Accounting Policies [Line Items]
Foreign currency translation			$ (24,300)	$ 2,000
United Kingdom | Research and Development Expense
Summary Of Significant Accounting Policies [Line Items]
Balance at beginning of period	$ 16,649	$ 21,044	30,723	17,344
Recognition of credit claims as offset to research and development expense	1,764	4,246	5,101	7,800
Receipt of credit claims	(1,916)		(18,390)
Foreign currency translation	(1,321)	81	(2,258)	227
Balance at end of period	$ 15,176	$ 25,371	$ 15,176	$ 25,371