Share-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2022

Share-Based Payment Arrangement [Abstract]

Summary of Option Activity

The following table summarizes option activity under the plans for the six months ended June 30, 2022:

	Number of Options			Weighted Average Exercise Price
Outstanding at December 31, 2021		17,300,740		$	6.57
Granted		3,165,732			0.56
Exercised		(397,534	)		0.00
Forfeited		(2,845,240	)		7.13
Outstanding at June 30, 2022		17,223,698		$	5.52
Vested and expected to vest as of June 30, 2022		17,223,698		$	5.52
Exercisable June 30, 2022		8,268,318		$	6.84

Summary of Award Activity

The following table summarizes award activity for the six months ended June 30, 2022:

	Performance-based RSUs		Time-based RSUs			Total RSUs			Weighted Average Grant Date Fair Value
Unvested and outstanding at December 31, 2021		195,000		123,333			318,333		$	6.41
Granted		—		2,112,842			2,112,842			0.46
Vested		—		(6,667	)		(6,667	)		(5.98	)
Forfeited		—		(71,800	)		(71,800	)		0.46
Unvested and outstanding at June 30, 2022		195,000		2,157,708			2,352,708		$	0.67

Share-based Compensation Expense

Share-based compensation expense recorded as research and development and general and administrative expenses is as follows (amounts in thousands):

	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
Research and development	$	1,744	$	2,135	$	3,706	$	5,011
General and administrative		2,212		3,406		4,910		6,798
	$	3,956	$	5,541	$	8,616	$	11,809