X0306 4 2019-03-06 0 0001645460 Cue Biopharma, Inc. CUE 0001748840 Mancilla Bethany 21 ERIE STREET CAMBRIDGE MA 02139 0 1 0 0 SVP and Chief Business Officer Stock Option (right to buy) 6.42 2019-03-06 4 A 0 65000 0.00 A 2029-03-06 Common Stock 65000 65000 D Stock Option (right to buy) 9.54 2019-03-06 4 A 0 100000 0.00 A 2025-08-01 Common Stock 100000 100000 D This stock option grant becomes exercisable in eight equal semi-annual installments beginning September 6, 2019. Represents a stock option award granted on August 1, 2018 that partially vested upon the achievement of certain performance based conditions as determined by the Compensation Committee of Cue Biopharma, Inc. on March 6, 2019. As of March 6, 2019, 50,000 of these options were vested and exercisable. The remaining 50,000 will become vested and exercisable only upon the achievement of certain performance based conditions. /s/ Bethany Mancilla by Mark Busch, as attorney-in-fact 2019-03-08