X0306 4 2022-06-09 0 0001828522 eFFECTOR Therapeutics, Inc. EFTR 0001748622 Bhatt Elizabeth C/O EFFECTOR THERAPEUTICS, INC. 142 NORTH CEDROS AVENUE, SUITE B SOLANA BEACH CA 92075 1 0 0 0 Stock Option (Right to Buy) 1.65 2022-06-09 4 A 0 20000 0.00 A 2032-06-08 Common Stock 20000 20000 D The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. The option shall vest in full on the earlier to occur of (A) the first anniversary of the date of grant or (B) the next occurring annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service on the board of directors of the Issuer through such vesting date. /s/ Michael Byrnes, Attorney-in-Fact for Elizabeth Bhatt 2022-06-13