X0508 4 2025-02-19 0000318154 AMGEN INC AMGN 0001748434 REESE DAVID M ONE AMGEN CENTER DRIVE THOUSAND OAKS CA 91320 1 EVP & Chief Technology Officer 0 Common Stock 2025-02-19 4 M 0 8711 156.35 A 70858 D Common Stock 2025-02-19 4 S 0 8711 293.2182 D 62147 D Common Stock 2025-02-21 4 S 0 25225 304.441 D 36922 D Nqso (Right to Buy) 156.35 2025-02-19 4 M 0 8711 0 D 2018-05-03 2026-05-03 Common Stock 8711 0 D These shares were acquired in connection with the exercise of stock options expiring on May 3, 2026. The price reported is an average price. The prices ranged from $291.90 to $295.97 per share. Full information regarding the number of shares purchased at each separate price within the range is available upon request by the SEC staff, the issuer or a security holder of the issuer. The price reported is an average price. The prices ranged from $297.19 to $305.33 per share. Full information regarding the number of shares purchased at each separate price within the range is available upon request by the SEC staff, the issuer or a security holder of the issuer. These shares include 707 Dividend Equivalents (DEs) granted pursuant to the Amgen Inc. Second Amended and Restated 2009 Equity Incentive Plan and subject to a qualifying dividend reinvestment plan. DEs are credited to the reporting person's unvested RSUs and are paid out in shares of the Company's common stock on a one-to-one basis according to the vesting schedule, along with a cash payment for any remaining fractional share amount. /s/ David M. Reese 2025-02-21