X0306 4 2021-06-01 0 0001656634 Gritstone bio, Inc. GRTS 0001746830 Agarwal Shefali C/O GRITSTONE BIO, INC. 5959 HORTON STREET, SUITE 300 EMERYVILLE CA 94608 1 0 0 0 Stock Option (Right to Buy) 9.48 2021-06-01 4 A 0 38000 0 A 2031-05-31 Common Stock 38000 38000 D Shares subject to the stock option vest and become exercisable on a monthly basis in equal monthly installments over a 36 month period commencing on the grant date, so that all shares subject to the stock option will become fully vested and exercisable on the third anniversary of the grant date, subject to the Reporting Person remaining a service provider through each monthly anniversary of the grant date. /s/ Rahsaan Thompson, Attorney-in-Fact for Shefali Agarwal 2021-11-19