Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Cash flows from operating activities
Net loss	$ (149,344)	$ (210,304)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation expense	1,696	2,125
Stock-based compensation expense	26,234	37,626
Gain on sale of property plant and equipment	(44)	0
Non-cash operating lease expense	3,277	3,451
Amortization (accretion) on short-term investments	3,956	2,510
Loss on extinguishment of debt	1,828	0
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	2,541	4,717
Other non-current assets	43	(43)
Accounts payable	(5,480)	1,428
Accrued liabilities	(12,167)	3,807
Operating lease liabilities	(876)	(820)
Net cash used in operating activities	(128,336)	(155,503)
Cash flows from investing activities
Purchase of short-term investments	(203,404)	(211,285)
Maturity of short-term investments	337,913	355,473
Purchase of property and equipment	(374)	(3,848)
Proceeds from sale of property, plant and equipment	155	0
Net cash provided by investing activities	134,290	140,340
Cash flows from financing activities
Proceeds from issuances of common stock under benefit plans	570	3,207
Payment of debt	(32,267)	0
Proceeds from term loan, net of issuance costs	0	19,910
Net cash (used in) provided by financing activities	(31,697)	23,117
Net (decrease) increase in cash and cash equivalents	(25,743)	7,954
Cash, cash equivalents and restricted cash at beginning of period	46,927	72,670
Cash, cash equivalents and restricted cash at end of period	72,670	64,716
Supplemental disclosures of cash flow information:
Cash paid for interest	2,539	2,620
Reconciliation of cash, cash equivalents, and restricted cash reported in the balance sheets
Cash and cash equivalents	45,445	71,188
Restricted cash	1,482	1,482
Total cash, cash equivalents, and restricted cash shown in the statements of cash flows	46,927	72,670
Supplemental disclosures of noncash investing and financing activities:
Purchase of property and equipment in accounts payable	112	236
Supplemental disclosures of cash flow information related to leases:
Cash paid for operating lease liabilities in operating cash flows	5,562	4,698
Right-of-use assets obtained in exchange for new operating lease liabilities	$ 0	$ 29,779