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Stock-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2025
Share-Based Payment Arrangement [Abstract]  
Schedule of Black-Scholes Option Pricing Model to Estimate Stock-based Compensation Expense for Stock Option Awards
The Company used Black-Scholes option pricing model to estimate stock-based compensation expense for stock option awards with the following assumptions:
Year Ended December 31,
20252024
MinMaxMinMax
Expected volatility86.82%89.30%85.02%88.02%
Risk-free interest rate3.98%4.45%3.45%4.60%
Expected dividend————
Expected term (in years)5.346.085.316.08
Underlying common stock fair value$1.37$12.63$11.09$17.44
Schedule of Option Activity Under the 2015 Plan and 2020 Plan
A summary of option activity under the 2015 Plan, 2020 Plan and Inducement Plan is as follows:
Number
of
Options		Weighted-
Average Exercise
Price per Share		Weighted-
Average
Remaining
Contractual
Term (in Years)		Aggregate
Intrinsic
Value (in thousands)
Outstanding as of December 31, 20248,300,804 $17.23 7.5$13,769 
Granted2,271,680 $9.68 
Exercised(4,921)$12.18 
Forfeited(3,111,497)$16.40 
Outstanding as of December 31, 20257,456,066 $15.28 5.6$— 
Exercisable as of December 31, 20255,305,752 $15.98 4.8$— 
Vested and expected to vest as of December 31, 20257,456,066 $15.28 5.6$— 
Schedule of Restricted Stock Activity The following table sets forth the outstanding RSUs and related activity for the year ended December 31, 2025:
Restricted Stock UnitsWeighted Average Grant Date Fair Value
Unvested and outstanding as of December 31, 2024932,634 $24.28 
Granted840,341 $10.67 
Released(372,313)$26.02 
Forfeited(542,415)$15.04 
Unvested and outstanding as of December 31, 2025858,247 $16.04 
Schedule of Black-Scholes Option Pricing Model to Estimate Stock-based Compensation Expense for 2020 Employee Stock Purchase Plan
The Company used the Black-Scholes option pricing model to estimate stock-based compensation expense for the 2020 ESPP with the following assumptions:
Year Ended December 31,
20252024
Risk-free interest rate
3.99% - 4.29%
4.80% -5.27%
Expected term of options (in years)0.500.50
Expected stock price volatility
70.91% - 208.00%
50.95% - 63.92%
Expected dividends—%—%
Schedule of Classification of Stock-based Compensation Expense
The following table presents the classification of stock-based compensation expense during the years ended December 31, 2025, and 2024 (in thousands):
Year Ended December 31,
20252024
Stock options and ESPP$18,065 $24,764 
Restricted stock units8,171 11,585 
Performance-based restricted stock units— 1,277 
Total stock-based compensation expense$26,236 $37,626 
Research and development expenses$9,983 $14,108 
General and administrative expenses$16,253 $23,518