Condensed Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2025	Sep. 30, 2024
Cash flows from operating activities
Net loss	$ (125,767)	$ (160,572)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation expense	1,331	1,667
Stock-based compensation expense	21,709	29,209
Gain on sale of property plant and equipment	(44)	0
Non-cash operating lease expense	2,449	2,640
Net amortization (accretion) on short-term investments and debt	3,674	1,945
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	2,750	5,739
Other non-current assets	43	(35)
Accounts payable	(5,477)	2,358
Accrued liabilities	(10,653)	9,935
Operating lease liabilities	(563)	(727)
Net cash used in operating activities	(110,548)	(107,841)
Cash flows from investing activities
Purchase of short-term investments	(118,319)	(177,930)
Maturity of short-term investments	251,059	282,777
Purchase of property and equipment	(374)	(3,639)
Proceeds from sale of property, plant and equipment	156	0
Net cash provided by investing activities	132,522	101,208
Cash flows from financing activities
Proceeds from issuances of common stock under benefit plans	570	3,106
Proceeds from term loan, net of issuance costs	0	19,909
Net cash provided by financing activities	570	23,015
Net increase in cash and cash equivalents	22,544	16,382
Cash and cash equivalents and restricted cash at beginning of period	72,670	64,716
Cash, cash equivalents and restricted cash at end of period	95,214	81,098
Supplemental disclosures of cash flow information:
Cash paid for interest	2,192	1,850
Reconciliation of cash, cash equivalents, and restricted cash reported in the balance sheets
Cash and cash equivalents	93,732	79,616
Restricted cash	1,482	1,482
Total cash, cash equivalents, and restricted cash	95,214	81,098
Supplemental disclosures of noncash investing and financing activities:
Net unrealized gain on short-term investments	(287)	503
Purchase of property and equipment in accounts payable and accrued liabilities	112	132
Supplemental disclosures of cash flow information related to leases:
Right-of-use assets obtained in exchange for new operating lease liabilities	$ 0	$ 29,779