Condensed Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2025	Mar. 31, 2024
Cash flows from operating activities
Net loss	$ (56,166)	$ (46,955)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation expense	448	513
Stock-based compensation expense	8,913	9,666
Non-cash operating lease expense	813	681
Net amortization (accretion) on short-term investments and debt	1,362	1,091
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	995	3,749
Other non-current assets	8	0
Accounts payable	(338)	2,257
Accrued liabilities	(4,808)	(910)
Operating lease liabilities	(91)	(363)
Net cash used in operating activities	(48,864)	(30,271)
Cash flows from investing activities
Purchase of short-term investments	(14,149)	(52,375)
Maturity of short-term investments	83,525	113,413
Purchase of property and equipment	(262)	(1,492)
Net cash provided by investing activities	69,114	59,546
Cash flows from financing activities
Proceeds from issuances of common stock under benefit plans	498	1,879
Proceeds from term loan, net of issuance costs	0	19,909
Net cash provided by financing activities	498	21,788
Net increase in cash and cash equivalents	20,748	51,063
Cash and cash equivalents and restricted cash at beginning of period	72,670	64,716
Cash, cash equivalents and restricted cash at end of period	93,418	115,779
Supplemental disclosures of cash flow information:
Cash paid for interest	723	501
Reconciliation of cash, cash equivalents, and restricted cash reported in the balance sheets
Cash and cash equivalents	91,936	114,297
Restricted cash	1,482	1,482
Total cash, cash equivalents, and restricted cash	93,418	115,779
Supplemental disclosures of noncash investing and financing activities:
Net unrealized gain on short-term investments	(162)	(834)
Purchase of property and equipment in accounts payable and accrued liabilities	132	1,059
Supplemental disclosures of cash flow information related to leases:
Right-of-use assets obtained in exchange for new operating lease liabilities	$ 0	$ 23,698