SCHEDULE 13G/A 0001425738 XXXXXXXX LIVE 1 Common Stock, par value $0.0001 per share 12/31/2024 0001746473 Pliant Therapeutics, Inc. 729139105 331 Oyster Point Blvd. South San Francisco CA 94080 Rule 13d-1(b) Redmile Group, LLC DE 0.00 2895478.00 0.00 2895478.00 2895478.00 N 4.8 IA OO Redmile Group, LLC's beneficial ownership of the Issuer's Common Stock ("Common Stock") is comprised of 2,895,478 shares of Common Stock owned by certain private investment vehicles managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. Percentage based on 60,853,623 shares of Common Stock outstanding as of November 1, 2024, as reported by the Issuer in its Form 10-Q for the quarterly period ended September 30, 2024 filed with the Securities and Exchange Commission on November 7, 2024 (the "Form 10-Q"). Jeremy C. Green X0 0.00 2895478.00 0.00 2895478.00 2895478.00 N 4.8 HC IN Jeremy C. Green's beneficial ownership of Common Stock is comprised of 2,895,478 shares of Common Stock owned by certain private investment vehicles managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. Percentage based on 60,853,623 shares of Common Stock outstanding as of November 1, 2024, as reported by the Issuer in the Form 10-Q. Pliant Therapeutics, Inc. 331 Oyster Point Boulevard, South San Francisco, CA, 94080 Redmile Group, LLC Jeremy C. Green Redmile Group, LLC One Letterman Drive Building D, Suite D3-300 The Presidio of San Francisco San Francisco, California 94129 Jeremy C. Green c/o Redmile Group, LLC (NY Office) 45 W. 27th Street, Floor 11 New York, NY 10001 Redmile Group, LLC: Delaware Jeremy C. Green: United Kingdom N IA HC Redmile Group, LLC - 2,895,478 (1) Jeremy C. Green - 2,895,478 (1) Redmile Group, LLC - 4.8% (2) Jeremy C. Green - 4.8% (2) Redmile Group, LLC - 0 Jeremy C. Green - 0 Redmile Group, LLC - 2,895,478 (1) Jeremy C. Green - 2,895,478 (1) Redmile Group, LLC - 0 Jeremy C. Green - 0 Redmile Group, LLC - 2,895,478 (1) Jeremy C. Green - 2,895,478 (1) (1) Redmile Group, LLC's and Jeremy C. Green's beneficial ownership of the Issuer's Common Stock is comprised of 2,895,478 shares of Common Stock owned by certain private investment vehicles managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. (2) Percentage based on 60,853,623 shares of Common Stock outstanding as of November 1, 2024, as reported by the Issuer in the Form 10-Q. N Y Y N See the response to Item 4. Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Redmile Group, LLC /s/ Jeremy C. Green 02/14/2025 Jeremy C. Green /s/ Jeremy C. Green 02/14/2025