X0306 4 2021-01-23 0 0001746473 PLIANT THERAPEUTICS, INC. PLRX 0001614741 Lefebvre Eric C/O PLIANT THERAPEUTICS, INC. 260 LITTLEFIELD AVENUE SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Medical Officer Stock Option (right to buy) 26.50 2021-01-23 4 A 0 73250 0.00 A 2031-01-22 Common Stock 73250 73250 D 1/48th of the shares subject to such option vest and become exercisable in substantially equal installments on each monthly anniversary of January 1, 2021, subject to the Reporting Person's continuous service to the Issuer on each such date. /s/ Mike Ouimette, attorney-in-fact 2021-01-26