<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001797818</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001746466</issuerCik>
      <issuerName>Equillium, Inc.</issuerName>
      <secFileNumber>001-38692</secFileNumber>
      <issuerAddress>
        <com:street1>2223 AVENIDA DE LA PLAYA</com:street1>
        <com:street2>SUITE 105</com:street2>
        <com:city>LA JOLLA</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92037</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(858) 412-5302</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Zedelmayer Christine</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Maxim Group</name>
        <address>
          <com:street1>300 Park Ave</com:street1>
          <com:street2>16th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>181219</noOfUnitsSold>
      <aggregateMarketValue>320757.00</aggregateMarketValue>
      <noOfUnitsOutstanding>60893283</noOfUnitsOutstanding>
      <approxSaleDate>03/09/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>04/22/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>152361</amountOfSecuritiesAcquired>
      <paymentDate>03/09/2026</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/10/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>7925</amountOfSecuritiesAcquired>
      <paymentDate>03/09/2026</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/10/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>9033</amountOfSecuritiesAcquired>
      <paymentDate>06/03/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/09/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11900</amountOfSecuritiesAcquired>
      <paymentDate>03/09/2026</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christine Zedelmayer</name>
        <address>
          <com:street1>2223 AVENIDA DE LA PLAYA</com:street1>
          <com:street2>SUITE 105</com:street2>
          <com:city>LA JOLLA</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92037</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>11/25/2025</saleDate>
      <amountOfSecuritiesSold>8098</amountOfSecuritiesSold>
      <grossProceeds>7696.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christine Zedelmayer</name>
        <address>
          <com:street1>2223 AVENIDA DE LA PLAYA</com:street1>
          <com:street2>SUITE 105</com:street2>
          <com:city>LA JOLLA</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92037</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>12/12/2025</saleDate>
      <amountOfSecuritiesSold>23804</amountOfSecuritiesSold>
      <grossProceeds>31897.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christine Zedelmayer</name>
        <address>
          <com:street1>2223 AVENIDA DE LA PLAYA</com:street1>
          <com:street2>SUITE 105</com:street2>
          <com:city>LA JOLLA</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92037</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>12/15/2025</saleDate>
      <amountOfSecuritiesSold>11900</amountOfSecuritiesSold>
      <grossProceeds>15589.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Christine Zedelmayer</name>
        <address>
          <com:street1>2223 AVENIDA DE LA PLAYA</com:street1>
          <com:street2>SUITE 105</com:street2>
          <com:city>LA JOLLA</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92037</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>02/19/2026</saleDate>
      <amountOfSecuritiesSold>185937</amountOfSecuritiesSold>
      <grossProceeds>322476.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>03/09/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/27/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Dominick Iadicicco, as a duly authorized representative of Maxim Group LLC., as attorney-in-fact for Christine Zedelmayer</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
