<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001797818</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001746466</issuerCik>
      <issuerName>Equillium, Inc.</issuerName>
      <secFileNumber>001-38692</secFileNumber>
      <issuerAddress>
        <com:street1>2223 AVENIDA DE LA PLAYA</com:street1>
        <com:street2>SUITE 105</com:street2>
        <com:city>LA JOLLA</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92037</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(858) 412-5302</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Zedelmayer Christine</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock </securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Maxim Group</name>
        <address>
          <com:street1>300 Park Ave</com:street1>
          <com:street2>16th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>8098</noOfUnitsSold>
      <aggregateMarketValue>7428.00</aggregateMarketValue>
      <noOfUnitsOutstanding>60893283</noOfUnitsOutstanding>
      <approxSaleDate>11/25/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ </securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>10/16/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock </natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>8098</amountOfSecuritiesAcquired>
      <paymentDate>11/25/2025</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>11/25/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/27/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Dominick Iadicicco, as a duly authorized representative of Maxim Group LLC., as attorney-in-fact for Christine Zedelmayer</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
