<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001797818</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001746466</issuerCik>
      <issuerName>Equillium, Inc.</issuerName>
      <secFileNumber>001-38692</secFileNumber>
      <issuerAddress>
        <com:street1>2223 AVENIDA DE LA PLAYA</com:street1>
        <com:street2>SUITE 105</com:street2>
        <com:city>LA JOLLA</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92037</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(858) 412-5302</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Zedelmayer Christine</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Maxim Group</name>
        <address>
          <com:street1>300 Park Ave, 16th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10010</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>15000</noOfUnitsSold>
      <aggregateMarketValue>18750.00</aggregateMarketValue>
      <noOfUnitsOutstanding>35254752</noOfUnitsOutstanding>
      <approxSaleDate>10/28/2024</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/19/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>15000</amountOfSecuritiesAcquired>
      <paymentDate>06/19/2023</paymentDate>
      <natureOfPayment>CASH</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/31/2024</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>07/19/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>CHRISTINE ZEDELMAYER</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
