<?xml version="1.0"?>
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    <periodOfReport>2020-09-17</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001701541</issuerCik>
        <issuerName>Black Diamond Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>BDTX</issuerTradingSymbol>
    </issuer>

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            <rptOwnerCik>0001687880</rptOwnerCik>
            <rptOwnerName>Versant Venture Capital VI, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
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            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001745961</rptOwnerCik>
            <rptOwnerName>Versant Voyageurs I Parallel, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
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    </reportingOwner>

    <reportingOwner>
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            <rptOwnerName>Versant Voyageurs I, L.P.</rptOwnerName>
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        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET</rptOwnerStreet1>
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            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
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    </reportingOwner>

    <reportingOwner>
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            <rptOwnerName>Versant Vantage I, L.P.</rptOwnerName>
        </reportingOwnerId>
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            <rptOwnerStreet2>SUITE 3630</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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    </reportingOwner>

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                    <value>See Footnote</value>
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                    <value>See Footnote</value>
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                    <value>See Footnote</value>
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                    <value>See Footnote</value>
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                    <value>See Footnote</value>
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    <footnotes>
        <footnote id="F1">Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Venture Capital VI, L.P. (&quot;Versant VI&quot;), to its partners.</footnote>
        <footnote id="F2">Shares held by Versant VI. Versant Ventures VI GP, L.P. (&quot;Versant Ventures VI GP&quot;) is the general partner of Versant VI, and Versant Ventures VI GP-GP, LLC (&quot;Versant Ventures VI GP-GP&quot;) is the general partner of Versant Ventures VI GP. Bradley J. Bolzon is a managing member of Versant Ventures VI GP-GP and may be deemed to share voting and dispositive power over the shares held by Versant VI; however, he disclaims beneficial ownership of such securities, except to the extent of his pecuniary interests therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F3">Represents a change in the form of ownership of Versant Ventures VI GP by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by Versant VI.</footnote>
        <footnote id="F4">Shares held by Versant Ventures VI GP. Versant Ventures VI GP-GP is the general partner of Versant Ventures VI GP. Bradley J. Bolzon is a managing member of Versant Ventures VI GP-GP and may be deemed to share voting and dispositive power over the shares held by Versant Ventures VI GP; however, he disclaims beneficial ownership of such securities, except to the extent of his pecuniary interests therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F5">Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Ventures VI GP to its partners.</footnote>
        <footnote id="F6">Represents a change in the form of ownership of Versant Ventures VI GP-GP by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by Versant Ventures VI GP.</footnote>
        <footnote id="F7">Shares held by Versant Ventures VI GP-GP. Bradley J. Bolzon is a managing member of Versant Ventures VI GP-GP and may be deemed to share voting and dispositive power over the shares held by Versant Ventures VI GP-GP; however, he disclaims beneficial ownership of such securities, except to the extent of his pecuniary interests therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F8">Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Ventures VI GP-GP to its members.</footnote>
        <footnote id="F9">Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Vantage I, L.P. (&quot;Versant Vantage I&quot;), to its partners, pursuant to a Rule 10b5-1 distribution plan.</footnote>
        <footnote id="F10">Shares held by Versant Vantage I. Versant Vantage I GP, L.P. (&quot;Versant Vantage I GP LP&quot;) is the general partner of Versant Vantage I, and Versant Vantage I GP-GP, LLC (&quot;Versant Vantage I GP-GP&quot;) is the general partner of Versant Vantage I GP LP. Bradley J. Bolzon is a managing member of Versant Vantage I GP-GP and may be deemed to share voting and dispositive power over the shares held by Versant Vantage I; however, he disclaims beneficial ownership of such securities, except to the extent of his pecuniary interests therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F11">Represents a change in the form of ownership of Versant Vantage I GP LP by virtue of the receipt of shares in the pro-rata in-kind distribution of common stock of the Issuer for no consideration by Versant Vantage I.</footnote>
        <footnote id="F12">Shares held by Versant Vantage I GP LP. Versant Vantage I GP-GP is the general partner of Versant Vantage I GP LP. Bradley J. Bolzon is a managing member of Versant Vantage I GP-GP and may be deemed to share voting and dispositive power over the shares held by Versant Vantage I GP LP; however, he disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F13">Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Vantage I GP LP, to its partners.</footnote>
        <footnote id="F14">Represents a change in the form of ownership of Versant Vantage I GP-GP by virtue of the receipt of shares in the pro-rata in-kind distribution of common stock of the Issuer for no consideration by Versant Vantage I GP LP.</footnote>
        <footnote id="F15">Shares held by Versant Vantage I GP-GP. Bradley J. Bolzon is a managing member of Versant Vantage I GP-GP and may be deemed to share voting and dispositive power over the shares held Versant Vantage I GP-GP; however, he disclaims beneficial ownership of such securities, except to the extent of his pecuniary interests therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F16">Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Vantage I GP-GP, to its members.</footnote>
        <footnote id="F17">Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Voyageurs I, L.P. (&quot;Versant Voyageurs I&quot;), to its partners, pursuant to a Rule 10b5-1 distribution plan.</footnote>
        <footnote id="F18">Shares held by Versant Voyageurs I. Versant Voyageurs I GP Company (&quot;Versant Voyageurs I GP&quot;) is the general partner of Versant Voyageurs I. Bradley J. Bolzon may be deemed to share voting and dispositive power over the shares held by Versant Voyageurs I; however, he disclaims beneficial ownership of such securities, except to the extent of his pecuniary interests therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F19">Represents a change in the form of ownership of Versant Voyageurs I GP, L.P. (&quot;Versant Voyageurs I GP LP&quot;) by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by Versant Voyageurs I.</footnote>
        <footnote id="F20">Shares held by Versant Voyageurs I GP LP. Bradley J. Bolzon is a partner of Versant Voyageurs I GP LP and may be deemed to share voting and dispositive power over the shares held by Versant Voyageurs I GP LP; however, he disclaims beneficial ownership of such securities, except to the extent of his pecuniary interests therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F21">Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Voyageurs I Parallel, L.P. (&quot;Versant I Parallel&quot;), to its partners, pursuant to a Rule 10b5-1 distribution plan.</footnote>
        <footnote id="F22">Shares held by Versant I Parallel. Versant Voyageurs I GP LP is the general partner of Versant I Parallel. Versant Ventures VI GP is the general partner of Versant Voyageurs I GP LP. Versant Ventures VI GP-GP is the general partner of Versant Ventures VI GP. Bradley J. Bolzon is a managing member of Versant Ventures VI GP-GP and may be deemed to share voting and dispositive power over the shares held by Versant I Parallel; however, he disclaims beneficial ownership of such securities, except to the extent of his pecuniary interests therein. Bradley J. Bolzon is a director of the Issuer and, accordingly, files separate Section 16 reports.</footnote>
        <footnote id="F23">Represents a change in the form of ownership of Versant Voyageurs I GP LP by virtue of the receipt of shares in the pro-rata in-kind distribution of common stock of the Issuer for no consideration by Versant I Parallel.</footnote>
        <footnote id="F24">Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by Versant Voyageurs I GP LP, to its partners.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Versant Venture Capital VI, L.P. By: Versant Ventures VI GP, L.P. Its: General Partner By: Versant Ventures VI GP-GP, LLC By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2020-09-21</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Voyageurs I Parallel, L.P. By: Versant Voyageurs I GP, L.P. Its: General Partner By: Versant Ventures VI GP, L.P. Its: General Partner By: Versant Ventures VI GP-GP, LLC By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2020-09-21</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Voyageurs I, L.P. By: Versant Voyageurs I GP Company Its: General Partner By: Robin L. Praeger Its: President</signatureName>
        <signatureDate>2020-09-21</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Versant Vantage I, LP By: Versant Vantage I GP, L.P. Its: General Partner By: Versant Vantage I GP-GP, LLC Its: General Partner By: Robin L. Praeger Its: Managing Director</signatureName>
        <signatureDate>2020-09-21</signatureDate>
    </ownerSignature>
</ownershipDocument>
