X0206 3 2018-07-17 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001745948 Freeman Mason C/O CRINETICS PHARMACEUTICALS, INC. 10222 BARNES CANYON ROAD, BLDG. #2 SAN DIEGO CA 92121 1 0 0 0 Stock Option (right to buy) 0.73 2025-12-10 Common Stock 54711 D 25% of the shares subject to the option vested on October 30, 2016, and 1/48th of the total remaining number of shares subject to the option vest monthly thereafter, subject to the Reporting Person's continued service to the Issuer on each such vesting date. The shares subject to the option are also subject to accelerated vesting as set forth in the stock option agreement between the Issuer and the Reporting Person. /s/ Marc Wilson, attorney-in-fact 2018-07-17