<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2021-07-29</periodOfReport>

    <issuer>
        <issuerCik>0000929545</issuerCik>
        <issuerName>CONDOR HOSPITALITY TRUST, INC.</issuerName>
        <issuerTradingSymbol>CDOR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001541551</rptOwnerCik>
            <rptOwnerName>EFANUR Stock Corp.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ITUZAING? 1377, PISOS 3, 4 Y 5</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MONTEVIDEO</rptOwnerCity>
            <rptOwnerState>X3</rptOwnerState>
            <rptOwnerZipCode>11000</rptOwnerZipCode>
            <rptOwnerStateDescription>URUGUAY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001476667</rptOwnerCik>
            <rptOwnerName>TYRUS STOCK CORP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>PLAZA INDEPENDENCIA 811, PB</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MONTEVIDEO</rptOwnerCity>
            <rptOwnerState>X3</rptOwnerState>
            <rptOwnerZipCode>11100</rptOwnerZipCode>
            <rptOwnerStateDescription>URUGUAY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001745533</rptOwnerCik>
            <rptOwnerName>Real Estate Investment Group VII L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O JIWIN S.A.</rptOwnerStreet1>
            <rptOwnerStreet2>CAMBARA 1620 OF 202</rptOwnerStreet2>
            <rptOwnerCity>MONTEVIDEO</rptOwnerCity>
            <rptOwnerState>X3</rptOwnerState>
            <rptOwnerZipCode>0000000000</rptOwnerZipCode>
            <rptOwnerStateDescription>URUGUAY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001478101</rptOwnerCik>
            <rptOwnerName>JIWIN STOCK CORP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>PLAZA INDEPENDENCIA 811, PB</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MONTEVIDEO</rptOwnerCity>
            <rptOwnerState>X3</rptOwnerState>
            <rptOwnerZipCode>11100</rptOwnerZipCode>
            <rptOwnerStateDescription>URUGUAY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2021-07-29</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1416586</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4754198</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Series E Cumulative Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
                <footnoteId id="F2"/>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2021-07-29</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>487738</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1416586</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The reporting group elected to exercise its right to require the Issuer to redeem all 487,738 shares of the Series E Stock (the &quot;Shares&quot;) held by the reporting group at a value per share equal to 130% of the $10 liquidation preference of the Shares, plus accrued and unpaid dividends, on July 29, 2021, pursuant to the terms of the Shares. The Issuer had the right to redeem the Shares with cash or by issuing shares of common stock, and a special committee of independent directors of the board of directors of the Issuer unanimously approved redemption of the Shares with shares of common stock. (Continued at Footnote 2)</footnote>
        <footnote id="F2">(Continued from Footnote 1) For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, the reporting group is deemed a Director by Deputization by virtue of its representation on the Board of Directors of the Issuer. The number of shares of common stock issued to effect redemption of the Shares equals 1,416,586 shares of common stock based on the weighted market sale price average of the common stock for the applicable thirty trading day period of $4.90 per share.</footnote>
    </footnotes>

    <remarks>This Form 4 is being filed in two parts due to the ten person reporting limitation of the electronic filing system. Part 1 is being filed by the following persons: Eduardo S. Elsztain, Consultores Assets Management, S.A., Consultores Venture Capital Limited, Cresud Sociedad Anonima Comercial Inmobiliara Financiera y Agropecuaria, Consultores Venture Capital Uruguay, SA, Agroinvestment S.A., Real Estate Strategies L.P., IRSA Inversiones y Representaciones Sociedad Anonima, IFIS Limited, and Inversiones Financieras del Sur S.A. Part 2 is being filed by the following persons: Efanur S.A., Tyrus S.A., Jiwin S.A. and Real Estate Investment Group VII L.P.</remarks>

    <ownerSignature>
        <signatureName>/s/ Efanur S.A. by Eduardo Elsztain, Chairman of the Board</signatureName>
        <signatureDate>2021-08-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Tyrus S.A. by Eduardo Elsztain, Chairman of the Board</signatureName>
        <signatureDate>2021-08-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Real Estate Investment Group VII L.P. by Eduardo Elsztain, Chairman of the Board</signatureName>
        <signatureDate>2021-08-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Jiwin S.A. by Eduardo Elsztain, Chairman of the Board</signatureName>
        <signatureDate>2021-08-11</signatureDate>
    </ownerSignature>
</ownershipDocument>
