Amount of cash outflow from acquisition of technology in connection with exclusive license agreement.

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The amount of aggregate milestone payments upon the achievement of specified clinical and regulatory milestones.

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The amount of aggregate milestone payments upon the achievement of specified clinical and regulatory milestones.

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Amount of fair value of anti-dilution of right liability.

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Amount of change in fair value of anti-dilution right liability.

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Amount of issuance date fair-value of anti-dilution liability.

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The amount of payment in connection with dosing of the first patient in our Phase two a clinical trial.

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Represents the amount of research and development expense upon achievement of clinical milestone.

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Amount of shares issued in connection with Amgen Agreement.

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Amount of upfront payment made in exchange for the rights.

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The equity interest of noncontrolling shareholders, partners or other equity holders in consolidated entity.

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Amount of other research and development expense.

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The cash outflow from amounts paid for the rights to manage the property.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Number of new stock issued during the period.

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Amgen license agreement (Details) - USD ($) $ in Thousands	1 Months Ended		12 Months Ended
Amgen license agreement (Details) - USD ($) $ in Thousands	Nov. 30, 2018	Jun. 30, 2018	Dec. 31, 2019	Dec. 31, 2018
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Share Issued value under agreement			$ 95,453
Initial fair value of the anti-dilution right liability				$ 1,639
Loss recognized related to change in fair value of the anti-dilution right liability prior to extinguishment				(5,765)
Research and development expense			37,046	11,882
Upfront cash payment				5,000
Fair value of issuance of the anti-dilution right liability				1,639
Amgen
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Payment for clinical trail			2,500
Amgen Agreement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Initial fair value of the anti-dilution right liability	$ 7,404
Amgen Agreement \| Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Aggregate milestone payments upon the achievement of specified clinical and regulatory milestones			37,500
Aggregate milestone payments upon the achievement of specified commercial milestones			75,000
Amgen Agreement \| Amgen
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Ownership interest of the outstanding shares (as a percent)		10.00%
Amgen Agreement \| Research and Development Expense
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Initial fair value of the anti-dilution right liability		$ 1,639
Research and development expense				8,016
Research and development expense upon achievement of clinical milestone			$ 2,500
Upfront cash payment				5,000
Fair value of shares of Series A Preferred Stock issued to Amgen				1,353
Fair value of issuance of the anti-dilution right liability				1,639
Other research and development expenses				24
Amgen Agreement \| Other expense
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Loss recognized related to change in fair value of the anti-dilution right liability prior to extinguishment				$ 5,765
Amgen Agreement \| Amgen
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Upfront payment		$ 5,000
Share Issued under agreement		2,653,333
Share Issued value under agreement		$ 1,353
Total consideration transferred to Amgen		$ 6,353
Amgen Agreement \| Series A Preferred Stock
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Share Issued under agreement	3,205,128
Amgen Agreement \| Series A Preferred Stock \| Second Tranche Closing
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Share Issued under agreement	3,205,128
Initial fair value of the anti-dilution right liability	$ 7,404
Amgen Agreement \| Series A Preferred Stock \| Amgen
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Share Issued under agreement		2,653,333
Share Issued value under agreement		$ 1,353