X0306 4 2022-03-01 0 0001744659 Akero Therapeutics, Inc. AKRO 0001778307 Cheng Andrew C/O AKERO THERAPEUTICS, INC. 601 GATEWAY BOULEVARD, SUITE 350 SOUTH SAN FRANCISCO CA 94080 1 1 0 0 President & CEO Common Stock 2022-03-01 4 M 0 10000 0.615 A 318996 D Common Stock 2022-03-01 4 S 0 10000 17.59 D 308996 D Stock Option (Right to Buy) 0.615 2022-03-01 4 M 0 10000 0 D 2028-10-17 Common Stock 10000 300868 D The reported transaction was effected pursuant to a Rule 10b5-1 trading plan dated December 2, 2021, previously adopted by the reporting person. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $17.33 to $17.95, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) to this Form 4. 25% of this option vested on October 1, 2019, and the remaining 75% of this option shall vest and become exercisable in 36 equal monthly installments thereafter. /s/ Jonathan Young, Attorney-in-Fact 2022-03-02