X0206 3 2018-06-27 0 0001693415 Translate Bio, Inc. TBIO 0001744627 Burgess Paul D. C/O TRANSLATE BIO, INC. 29 HARTWELL AVENUE LEXINGTON MA 02421 0 1 0 0 General Counsel and Secretary Common Stock 71833 D Stock Option (right to buy) 7.39 2027-12-21 Common Stock 219652 D Stock Option (right to buy) 8.34 2028-03-06 Common Stock 69954 D This option was granted on December 22, 2017. The shares underlying the option are scheduled to vest over four years in equal monthly installments through March 9, 2021. This option was granted on March 7, 2018. The shares underlying the option are scheduled to vest over four years, with 25% of the shares vesting on March 7, 2019 and the remainder vesting in equal monthly installments through March 7, 2022. Exhibit Index: 24.1 Power of Attorney /s/ Paul Burgess 2018-06-27