Restructuring, Impairment and Related Charges - Schedule of Activity Related to Restructuring Liabilities Associated to Restructuring Initiatives (Details) - USD ($) $ in Thousands	3 Months Ended	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2022
Restructuring Cost and Reserve [Line Items]
Restructuring liabilities, balance	$ 7,155
Reclassification of final payment obligation related to a manufacturing agreement that was recognized in the prior period (see Note 14)		$ 2,185
Restructuring, impairment and related charges	8,396	31,058
Cash payments	(4,328)	(8,195)
Noncash activities		(13,825)
Restructuring liabilities, balance	11,223	11,223
Accrued Compensation and Benefits
Restructuring Cost and Reserve [Line Items]
Restructuring liabilities, balance	2,223	2,223
Accrued Research and Development Liabilities
Restructuring Cost and Reserve [Line Items]
Restructuring liabilities, balance	6,000	6,000
Other Accrued Liabilities
Restructuring Cost and Reserve [Line Items]
Restructuring liabilities, balance	$ 3,000	$ 3,000