Condensed Consolidated Statements of Redeemable Convertible Noncontrolling Interests and Stockholders' Equity (Unaudited) - USD ($) $ in Thousands		Total		Cumulative Effect, Period of Adoption, Adjusted Balance	Equity Compensation Plans	Employee Stock Purchase Plan	Satisfy Tax Withholding	Redeemable Convertible Noncontrolling Interests		Common Stock	Common Stock Equity Compensation Plans	Common Stock Employee Stock Purchase Plan	Common Stock Satisfy Tax Withholding	Treasury Stock	Additional Paid-in Capital	Additional Paid-in Capital Cumulative Effect, Period of Adoption, Adjusted Balance	Additional Paid-in Capital Equity Compensation Plans	Additional Paid-in Capital Employee Stock Purchase Plan	Additional Paid-in Capital Satisfy Tax Withholding	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Accumulated Deficit Cumulative Effect, Period of Adoption, Adjusted Balance	Parent	Parent Cumulative Effect, Period of Adoption, Adjusted Balance	Parent Equity Compensation Plans	Parent Employee Stock Purchase Plan	Parent Satisfy Tax Withholding	Noncontrolling Interests
Beginning balance at Dec. 31, 2020	[1]	$ 106,256								$ 125				$ (75,000)	$ 1,021,344					$ 192	$ (888,755)		$ 57,906					$ 48,350
Beginning balance ((ASU 2020-06)) at Dec. 31, 2020				$ (153,750)												$ (168,078)						$ 14,328		$ (153,750)
Temporary equity, beginning balance at Dec. 31, 2020	[1]							$ 1,630
Beginning balance, shares at Dec. 31, 2020	[1]									122,849,389				2,414,681
Issuance of shares					$ 6,842	$ 1,651					$ 1						$ 6,841	$ 1,651							$ 6,842	$ 1,651
Issuance of shares, shares											819,113	65,298
Stock-based compensation		19,841													19,841								19,841
Purchase of capped calls		(61,295)													(61,295)								(61,295)
Repurchase of common stock		(50,000)												$ (50,000)									(50,000)
Repurchase of common stock, shares										(759,993)				759,993
Repurchase of shares to satisfy tax withholding							$ (1,021)												$ (1,021)								$ (1,021)
Repurchase of shares to satisfy tax withholding, shares													(15,653)
Repurchase of Eidos noncontrolling interests for cash and shares, including transaction costs of $70,734		(91,997)								$ 26					(53,856)								(53,830)					(38,167)
Repurchase of noncontrolling interests for cash and shares, including transaction costs shares										26,156,446
Issuance of noncontrolling interests		5,080																										5,080
Transfers from (to) noncontrolling interests		(517)													1,690								1,690					(2,207)
Temporary Equity, transfers from (to) noncontrolling interest								517
Unrealized gains (losses) on available-for-sale securities		(249)																		(249)			(249)
Net income (loss)		(170,206)																			(163,079)		(163,079)					(7,127)
Temporary Equity, net loss								(876)
Ending balance at Mar. 31, 2021		(389,365)								$ 152				$ (125,000)	767,117					(57)	(1,037,506)		(395,294)					5,929
Temporary equity, ending balance at Mar. 31, 2021								1,271
Ending balance, shares at Mar. 31, 2021										149,114,600				3,174,674
Beginning balance at Dec. 31, 2020	[1]	106,256								$ 125				$ (75,000)	1,021,344					192	(888,755)		57,906					48,350
Beginning balance ((ASU 2020-06)) at Dec. 31, 2020				$ (153,750)												$ (168,078)						$ 14,328		$ (153,750)
Temporary equity, beginning balance at Dec. 31, 2020	[1]							1,630
Beginning balance, shares at Dec. 31, 2020	[1]									122,849,389				2,414,681
Unrealized gains (losses) on available-for-sale securities		(156)
Ending balance at Jun. 30, 2021		(457,490)								$ 153				$ (130,308)	799,679					36	(1,133,854)		(464,294)					6,804
Temporary equity, ending balance at Jun. 30, 2021								1,865
Ending balance, shares at Jun. 30, 2021										149,614,740				3,279,368
Beginning balance at Mar. 31, 2021		(389,365)								$ 152				$ (125,000)	767,117					(57)	(1,037,506)		(395,294)					5,929
Temporary equity, beginning balance at Mar. 31, 2021								1,271
Beginning balance, shares at Mar. 31, 2021										149,114,600				3,174,674
Issuance of shares					3,751						$ 1						3,750								3,751
Issuance of shares, shares											646,250
Stock-based compensation		32,509													32,509								32,509
Repurchase of common stock		(5,308)												$ (5,308)									(5,308)
Repurchase of common stock, shares										(104,694)				104,694
Repurchase of shares to satisfy tax withholding							(2,281)												(2,281)								(2,281)
Repurchase of shares to satisfy tax withholding, shares													(41,416)
Fair value of PellePharm noncontrolling interest on consolidation								5,074
Issuance of noncontrolling interests		5																										5
Temporary Equity, issuance (repurchase) of noncontrolling interest								700
Transfers from (to) noncontrolling interests		3,618													(1,416)								(1,416)					5,034
Temporary Equity, transfers from (to) noncontrolling interest								(3,618)
Unrealized gains (losses) on available-for-sale securities		93																		93			93
Net income (loss)		(100,512)																			(96,348)		(96,348)					(4,164)
Temporary Equity, net loss								(1,562)
Ending balance at Jun. 30, 2021		(457,490)								$ 153				$ (130,308)	799,679					36	(1,133,854)		(464,294)					6,804
Temporary equity, ending balance at Jun. 30, 2021								1,865
Ending balance, shares at Jun. 30, 2021										149,614,740				3,279,368
Beginning balance at Dec. 31, 2021	[1]	(867,002)	[2]							$ 154				$ (275,000)	841,530					(132)	(1,436,966)		(870,414)					3,412
Temporary equity, beginning balance at Dec. 31, 2021		1,423						1,423	[1]
Beginning balance, shares at Dec. 31, 2021	[1]									147,343,323				6,191,761
Issuance of shares					104	$ 966											104	$ 966							104	$ 966
Issuance of shares, shares											229,926	127,635
Stock-based compensation		25,423													25,423								25,423
Repurchase of shares to satisfy tax withholding							(110)												(110)								(110)
Repurchase of shares to satisfy tax withholding, shares													(12,491)
Issuance of noncontrolling interests		89																										89
Transfers from (to) noncontrolling interests		48													(317)								(317)					365
Temporary Equity, transfers from (to) noncontrolling interest								(47)
Unrealized gains (losses) on available-for-sale securities		(251)																		(251)			(251)
Net income (loss)		(200,290)																			(196,397)		(196,397)					(3,893)
Temporary Equity, net loss								(1,040)
Ending balance at Mar. 31, 2022		(1,041,023)								$ 154				$ (275,000)	867,596					(383)	(1,633,363)		(1,040,996)					(27)
Temporary equity, ending balance at Mar. 31, 2022								336
Ending balance, shares at Mar. 31, 2022										147,688,393				6,191,761
Beginning balance at Dec. 31, 2021	[1]	(867,002)	[2]							$ 154				$ (275,000)	841,530					(132)	(1,436,966)		(870,414)					3,412
Temporary equity, beginning balance at Dec. 31, 2021		1,423						1,423	[1]
Beginning balance, shares at Dec. 31, 2021	[1]									147,343,323				6,191,761
Unrealized gains (losses) on available-for-sale securities		(295)
Ending balance at Jun. 30, 2022		(1,013,514)								$ 154				$ (275,000)	892,960					(427)	(1,643,219)		(1,025,532)					12,018
Temporary equity, ending balance at Jun. 30, 2022		(1,499)						(1,499)
Ending balance, shares at Jun. 30, 2022										148,243,197				6,191,761
Beginning balance at Mar. 31, 2022		(1,041,023)								$ 154				$ (275,000)	867,596					(383)	(1,633,363)		(1,040,996)					(27)
Temporary equity, beginning balance at Mar. 31, 2022								336
Beginning balance, shares at Mar. 31, 2022										147,688,393				6,191,761
Issuance of shares					$ 56												$ 56								$ 56
Issuance of shares, shares											609,058
Stock-based compensation		23,901													23,901								23,901
Repurchase of shares to satisfy tax withholding							$ (366)												$ (366)								$ (366)
Repurchase of shares to satisfy tax withholding, shares													(54,254)
Issuance of noncontrolling interests		4,686																										4,686
Transfers from (to) noncontrolling interests		(144)													1,773								1,773					(1,917)
Temporary Equity, transfers from (to) noncontrolling interest								144
Unrealized gains (losses) on available-for-sale securities		(44)																		(44)			(44)
Net income (loss)		(580)																			(9,856)		(9,856)					9,276
Temporary Equity, net loss								(1,979)
Ending balance at Jun. 30, 2022		(1,013,514)								$ 154				$ (275,000)	$ 892,960					$ (427)	$ (1,643,219)		$ (1,025,532)					$ 12,018
Temporary equity, ending balance at Jun. 30, 2022		$ (1,499)						$ (1,499)
Ending balance, shares at Jun. 30, 2022										148,243,197				6,191,761

[1] The consolidated balances as of December 31, 2021 and 2020 are derived from the audited consolidated financial statements as of those dates.

[2] The condensed consolidated balance sheet as of December 31, 2021 is derived from the audited consolidated financial statements as of that date.