X0306 4 2019-09-18 0 0001429560 TREVENA INC TRVN 0001741519 Demitrack Mark C/O TREVENA, INC. 955 CHESTERBROOK BLVD., SUITE 110 CHESTERBROOK PA 19087 0 1 0 0 Sr. VP & Chief Medical Officer Stock Option (Right to Buy) 1.00 2019-09-18 4 A 0 50000 0.00 A 2029-09-18 Common Stock 50000 50000 D The option shall vest and become exercisable with respect to one-sixteenth of the total number of shares subject to the option on a quarterly basis (every three months) from the Transaction Date listed above, subject to the reporting person's Continuous Service (as defined in the Trevena, Inc. 2013 Equity Incentive Plan, as amended) as of each such vesting date. /s/ Joel Solomon, Attorney-in-Fact 2019-09-20