X0508 4 2024-10-08 0001429560 TREVENA INC TRVN 0001741519 Demitrack Mark C/O TREVENA, INC. 955 CHESTERBROOK BOULEVARD, SUITE 110 CHESTERBROOK PA 19087 0 1 0 0 Acting CMO 0 Common Stock 2024-10-08 4 F 0 20 1.47 D 12228 D Common Stock 2024-10-08 4 F 0 45 1.47 D 12183 D Common Stock 2024-10-08 4 F 0 144 1.47 D 12039 D Common Stock 2024-10-08 4 F 0 144 1.47 D 11895 D Common Stock 2024-10-08 4 F 0 532 1.47 D 11363 D Reflects shares withheld in satisfaction of tax withholding obligations upon vesting and settlement of restricted stock units ("RSUs") granted on December 17, 2020. The Issuer effected a 1-for-25 reverse stock split of its common stock on August 13, 2024. The number of securities reported on this Form 4 has been adjusted to reflect the reverse stock split. Reflects shares withheld in satisfaction of tax withholding obligations upon vesting and settlement of RSUs granted on December 2, 2021. Reflects shares withheld in satisfaction of tax withholding obligations upon vesting and settlement of RSUs granted on January 6, 2023. Reflects shares withheld in satisfaction of tax withholding obligations upon vesting and settlement of performance stock units granted on January 6, 2023. Reflects shares withheld in satisfaction of tax withholding obligations upon vesting and settlement of RSUs granted on December 14, 2023. /s/ Jennifer Keyser, as Attorney-in-Fact 2024-10-10