X0306 4 2020-04-20 0 0001730430 Kiniksa Pharmaceuticals, Ltd. KNSA 0001741382 Beetham Thomas W. C/O KINIKSA PHARMACEUTICALS, LTD. CLARENDON HOUSE 2 CHURCH STREET HAMILTON D0 HM11 BERMUDA 0 1 0 0 EVP & Chief Legal Officer Class A Common Shares 2020-04-20 4 S 0 47423 19.06 D 32107 D Class A Common Shares 2020-04-21 4 S 0 1563 19.56 D 30544 D Class A Common Shares 2020-04-21 4 S 0 955 20.44 D 29589 D The sale of Class A Common Shares reported in this From 4 was effected pursuant to a Rule 10b5-1 plan executed by the reporting person on December 24, 2019. This transaction was executed in multiple trades through a broker-dealer at prices ranging from $19.00 to $19.17. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price. This transaction was executed in multiple trades through a broker-dealer at prices ranging from $19.07 to $20.05. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price. This transaction was executed in multiple trades through a broker-dealer at prices ranging from $20.12 to $20.60. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price. /s/ Thomas W. Beetham 2020-04-22