Income Taxes - Summary of Tax Effects of Temporary Differences Portions of Company's Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Net operating losses	$ 96,340	$ 77,467
Tax credits	43,696	33,753
Stock-based compensation	21,469	20,971
Accrued compensation and related expenses	3,690	3,012
Lease liabilities	19,780	20,475
Financing related	13,519	11,090
Intangible assets	75,059	75,093
Depreciation and amortization	4,766
Other	5,051	1,474
Total deferred tax assets:	283,370	243,335
Valuation allowance	(239,045)	(201,814)
Total deferred tax assets, net of valuation allowance:	44,325	41,521
Deferred tax liabilities:
Depreciation and amortization		(867)
Goodwill	(29,638)	(25,792)
Right-of-use assets	(17,060)	(17,565)
Total deferred tax liabilities:	(46,698)	(44,224)
Total net deferred tax liabilities:	$ (2,373)	$ (2,703)