Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Summary of Loss from Operations Before Income Taxes Categorized Geographically

Loss from operations before income taxes is categorized geographically as follows:

	Year Ended December 31,
(in thousands)	2021			2020			2019
United States	$	(101,742	)	$	(46,409	)	$	(81,653	)
Foreign		(21,025	)		(43,993	)		5,015
Total loss from operations before income taxes	$	(122,767	)	$	(90,402	)	$	(76,638	)

Schedule of Provision for (Benefit from) Income Taxes

The provision for (benefit from) income taxes consisted of the following:

	Year Ended December 31,
(in thousands)	2021			2020		2019
Current income tax expense:
Federal	$	—		$	—	$	14
State		119			28		10
Foreign		695			337		873
Total current income tax expense		814			365		897
Deferred income tax expense:
Federal		318			324		(1,087	)
State		261			3		121
Foreign		(911	)		487		(2,710	)
Total deferred income tax expense (benefit)		(332	)		814		(3,676	)
Total provision for (benefit from) income taxes	$	482		$	1,179	$	(2,779	)

Summary of Reconciliation of Company's Effective Tax Rate to Federal Statutory Rate

A reconciliation of the Company’s effective tax rate to the federal statutory rate is as follows:

	Year Ended December 31,
(in thousands)	2021			2020			2019
Tax at federal statutory rate	$	(25,781	)	$	(18,984	)	$	(16,094	)
State income tax, net of federal tax benefit		(6,517	)		(4,468	)		(4,102	)
Foreign tax rate differential		3,450			10,009			(2,651	)
Stock-based compensation		1,305			(3,429	)		1,885
Research and development credits		(3,752	)		(3,066	)		(2,033	)
Other		387			492			805
Change in valuation allowance		31,390			20,625			19,411
Total provision for (benefit from) income taxes	$	482		$	1,179		$	(2,779	)

Summary of Tax Effects of Temporary Differences Portions of Company's Deferred Tax Assets and Liabilities

As of December 31, 2021 and 2020, the tax effects of temporary differences that give rise to significant portions of the Company’s deferred tax assets and liabilities are as follows:

(in thousands)	December 31, 2021			December 31, 2020
Deferred tax assets:
Net operating losses	$	96,340		$	77,467
Tax credits		43,696			33,753
Stock-based compensation		21,469			20,971
Accrued compensation and related expenses		3,690			3,012
Lease liabilities		19,780			20,475
Financing related		13,519			11,090
Intangible assets		75,059			75,093
Depreciation and amortization		4,766			—
Other		5,051			1,474
Total deferred tax assets:		283,370			243,335
Valuation allowance		(239,045	)		(201,814	)
Total deferred tax assets, net of valuation allowance:		44,325			41,521
Deferred tax liabilities:
Depreciation and amortization		—			(867	)
Goodwill		(29,638	)		(25,792	)
Right-of-use assets		(17,060	)		(17,565	)
Total deferred tax liabilities:		(46,698	)		(44,224	)
Total net deferred tax liabilities:	$	(2,373	)	$	(2,703	)

Summary of Changes in Balances of Gross Unrecognized Tax Benefits

Changes in balances during 2021 and 2020 and ending balances as of December 31, 2021 and 2020 in gross unrecognized tax benefits were as follows:

(in thousands)	December 31, 2021		December 31, 2020
Beginning balances	$	6,867	$	4,905
Increases related to tax positions taken during a prior year		387		352
Increases related to tax positions taken during the current year		2,648		1,610
Decreases related to tax positions taken during a prior year		—		—
Decreases related to tax settlements with taxing authorities		—		—
Ending balances	$	9,902	$	6,867