CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018
Revenues	$ 240,031,000	$ 263,701,000
Cost of goods sold (inclusive of amortization of intangibles)	111,630,000	140,082,000
Gross profit	128,401,000	123,619,000
Selling, general and administrative expenses	93,030,000	74,243,000
Research and development expenses	32,319,000	43,693,000
Impairment of intangibles	283,747,000	17,903,000
Impairment of goodwill	0	86,318,000
Total operating expenses	409,096,000	222,157,000
Operating loss	(280,695,000)	(98,538,000)
Interest expense and amortization of debt discount	18,211,000	20,790,000
Other non-operating expense	(884,000)	(664,000)
Total other non-operating expense (gain)	(17,327,000)	(20,126,000)
Loss before income taxes	(298,022,000)	(118,664,000)
Income tax benefit	27,121,000	8,983,000
Net loss	(270,901,000)	(109,681,000)
Other comprehensive loss, net
Change in foreign currency translation adjustments	(383,000)	(1,213,000)
Comprehensive loss	$ (271,284,000)	$ (110,894,000)
Income (loss) per share attributable to shareholders
Loss per share attributable to shareholders, basic and diluted	$ (5.17)	$ (2.42)
Weighted average shares basic and diluted
Weighted average shares, basic and diluted	52,367,444	45,276,278
Product Revenue
Revenues	$ 235,472,000	$ 261,398,000
Royalty Revenue
Revenues	3,641,000	1,959,000
Licensing and Contract Revenue
Revenues	$ 918,000	$ 344,000