Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Cash flows from operating activities:
Net loss	$ (42,494)	$ (39,225)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	699	782
Gain on disposal of equipment	0	(70)
Share-based compensation	6,120	5,330
Amortization of premium and discount on marketable securities	(3,226)	(801)
ROU asset amortization	1,191	1,122
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	6,762	(5,591)
Accounts payable	708	2,515
Accrued expenses	(9,176)	2,915
Operating lease liability	(1,202)	(1,102)
Net cash used in operating activities	(40,618)	(34,125)
Cash flows from investing activities:
Purchases of marketable securities	(155,418)	(200,119)
Proceeds from sale or maturities of marketable securities	182,413	48,955
Purchases of property and equipment	(30)	(212)
Proceeds from sale of equipment	0	176
Net cash provided by (used) in investing activities	26,965	(151,200)
Cash flows from financing activities:
Proceeds from issuance of common stock	3,126	76,237
Issuance costs from issuance of common stock	(94)	(495)
Proceeds from exercise of stock options	62	15
Taxes related to the vesting of RSUs	159	(0)
Net cash provided by financing activities	2,935	75,757
Net change in cash and cash equivalents	(10,718)	(109,568)
Cash and cash equivalents at beginning of year	34,946	144,514
Cash and cash equivalents at end of year	24,228	34,946
Supplemental disclosure of cash flow information
Unrealized (gain) loss on marketable securities	$ (339)	$ 302