Note 10 - License, Research and Collaboration Agreements (Details Textual) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended
	Nov. 30, 2018	Dec. 31, 2023
ABL Bio Agreement [Member]
Upfront Payment	$ 5,000
License and Research Agreement, Future Payments	6,000
Milestone Payment Obligation	96,000
Maximum Development and Regulatory Milestone Payments	$ 303,000
Milestone Payments Paid		$ 110,000
ABL Bio Agreement [Member] | Ophthalmology [Member]
Maximum Development and Regulatory Milestone Payments		75,000
Adimab Agreement [Member]
Milestone Payment Obligation		2,000
Milestone Payments Paid		$ 0