Note 8 - Stockholders' Equity (Details Textual) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended				3 Months Ended	12 Months Ended
	Nov. 30, 2022	Dec. 31, 2021	Nov. 30, 2021	Jun. 30, 2021	Dec. 31, 2022	Dec. 31, 2022	Dec. 31, 2021
Proceeds from Issuance of Common Stock						$ 76,237	$ 128,267
Payments of Stock Issuance Costs						$ 495	$ 281
Common Stock [Member]
Shares Issued, Price Per Share (in dollars per share)				$ 5.00
Underwriting Public Offering [Member]
Shares Issued, Price Per Share (in dollars per share)			$ 3.50
Underwriting Public Offering [Member] | Common Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares)			35,715,000
Over-Allotment Option [Member]
Stock Issued During Period, Shares, New Issues (in shares)		3,271,857
Shares Issued, Price Per Share (in dollars per share)			$ 3.50
Option to Purchase Additional Shares of Common Stock (in shares)			5,357,250
Follow On Public Offering [Member]
Stock Issued During Period, Shares, New Issues (in shares)		38,986,857
Proceeds from Issuance or Sale of Equity, Total		$ 136,500
Underwriters Legal and Accounting Costs		8,500
Proceeds from Issuance of Common Stock		$ 128,000
Private Investment in Public Entity Offering [Member]
Stock Issued During Period, Shares, New Issues (in shares)	25,000,000
Shares Issued, Price Per Share (in dollars per share)	$ 3.21
Proceeds from Issuance of Common Stock	$ 80,300
Payments of Stock Issuance Costs	4,500
Proceeds from Issuance of Common Stock, Net	$ 75,700
Trigr Therapeutics, Inc. [Member]
Stock Issued During Period, Shares, Acquisitions (in shares)				10.3
Stock Cancelled During Period, Shares, Acquisitions (in shares)					95