Note 10 - License, Research and Collaboration Agreements (Details Textual) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended	9 Months Ended
Nov. 30, 2018	Sep. 30, 2022	Sep. 30, 2022
ABL Bio Agreement [Member]
Upfront Payment	$ 5,000
License and Research Agreement, Future Payments	6,000
Maximum Development and Regulatory Milestone Payments	110,000
ABL Bio Agreement [Member] \| Oncology [Member]
Maximum Commercial Milestone Payments and Royalties	$ 295,000
Adimab Agreement [Member]
Milestone Payments Paid			$ 0
Milestone Payment Obligation		$ 2,000	2,000
FUJIFILM Diosynth Biotechnologies Agreement [Member]
Cash Payment for License Agreement		0	500
Research and Development Expense, Total		89	2,900
License and Research Agreement, Expenses to be Recognized		600	600
FUJIFILM Diosynth Biotechnologies Agreement [Member] \| Maximum [Member]
License and Research Agreement, Expenses to be Recognized		$ 100	$ 100

The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 912
-SubTopic 730
-Section 25
-Paragraph 1
-URI https://asc.fasb.org/extlink&oid=6472174&loc=d3e58812-109433

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 985
-SubTopic 20
-Section 50
-Paragraph 1
-URI https://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756

Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 730
-SubTopic 10
-Section 50
-Paragraph 1
-URI https://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373

Name:	us-gaap_ResearchAndDevelopmentExpense
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration