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License Agreements (Details)
€ in Millions
3 Months Ended
Mar. 31, 2020
USD ($)
Mar. 31, 2019
USD ($)
Mar. 31, 2020
EUR (€)
Mar. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Nov. 01, 2019
USD ($)
Related Party Transaction [Line Items]            
Research and development $ 42,042,000 $ 23,403,000        
Accrued and other current liabilities       $ 19,619,000 $ 23,829,000 [1]  
Equity method investment       $ 4,829,000 4,892,000 [1]  
Research and development            
Related Party Transaction [Line Items]            
Collaboration arrangement, expense $ 300,000          
Notch Therapeutics, Inc.            
Related Party Transaction [Line Items]            
Equity method investment         4,900,000 $ 5,000,000.0
Ownership percentage     25.00% 25.00%   25.00%
Pfizer            
Related Party Transaction [Line Items]            
Royalty obligation period from date of first sale 12 years          
Pfizer | Asset Contribution Agreement            
Related Party Transaction [Line Items]            
Aggregate potential milestone payments $ 325,000,000.0          
Pfizer | Asset Contribution Agreement | Minimum            
Related Party Transaction [Line Items]            
Aggregate potential milestone payments 30,000,000.0          
Pfizer | Asset Contribution Agreement | Maximum            
Related Party Transaction [Line Items]            
Aggregate potential milestone payments 60,000,000.0          
Aggregate potential regulatory and development milestones 840,000,000.0          
Cellectis | Research Collaboration and License Agreement            
Related Party Transaction [Line Items]            
Maximum payments required per product against selected target 185,000,000.0          
Cellectis | Research Services | Research Collaboration and License Agreement            
Related Party Transaction [Line Items]            
Research and development 0 0        
Cellectis | Pre-Clinical Development Milestone | Research Collaboration and License Agreement            
Related Party Transaction [Line Items]            
Research and development 0 0        
Cellectis | Development and Sales | Maximum | Research Collaboration and License Agreement            
Related Party Transaction [Line Items]            
Aggregate potential milestone payments $ 2,800,000,000          
Servier | License and Collaboration Agreement            
Related Party Transaction [Line Items]            
Research and development   $ 700,000        
Percentage of development costs payable by the Company 60.00%          
Percentage of development cost payable by collaboration partner 40.00%          
Recovery of research and development expense $ 1,000,000.0          
Receivables       $ 200,000    
Accrued and other current liabilities         $ 2,200,000  
Servier | Regulatory Milestone | License and Collaboration Agreement            
Related Party Transaction [Line Items]            
Aggregate potential milestone receivable       42,000,000    
Servier | Regulatory Milestone | Maximum | License and Collaboration Agreement            
Related Party Transaction [Line Items]            
Aggregate potential milestone payments 137,500,000          
Servier | Sales Milestone | License and Collaboration Agreement            
Related Party Transaction [Line Items]            
Aggregate potential milestone receivable     € 70.5 77,400,000    
Servier | Sales Milestone | Maximum | License and Collaboration Agreement            
Related Party Transaction [Line Items]            
Aggregate potential milestone payments 78,000,000.0          
Notch Therapeutics, Inc. | Research Collaboration and License Agreement            
Related Party Transaction [Line Items]            
Aggregate potential milestone payable       $ 7,250,000    
Notch Therapeutics, Inc. | License and Collaboration Agreement            
Related Party Transaction [Line Items]            
Research and development 10,000,000          
Collaboration agreement, upfront payment           $ 10,000,000.0
Notch Therapeutics, Inc. | Pre-Clinical Development Milestone | Maximum | License and Collaboration Agreement            
Related Party Transaction [Line Items]            
Aggregate potential milestone payments 4,000,000.0          
Notch Therapeutics, Inc. | Clinical, Regulatory, and Commercial Milestone | Maximum | License and Collaboration Agreement            
Related Party Transaction [Line Items]            
Aggregate potential milestone payments $ 283,000,000.0          
[1] The balance sheet as of December 31, 2019 is derived from the audited financial statements as of that date.